长期从事肿瘤放射敏感性机制及核辐射损伤防治策略研究。主持国家自然科学基金项目5项，省部级项目7项。发表SCI论文100余篇，第一作者或通讯作者论文60余篇。2015年获得国家自然科学基金委优秀青年科学基金；先后入选中国核工业集团（原核工业部）青年英才、四川省高层次人才计划、四川省技术和学术带头人和四川省杰出青年科技人才。担任Oncol Res、Biologics（TARGETS & THERAPY）、Front Oncol、Exp Ther Med、中华放射医学和防护杂志、国际放射医学核医学杂志和新黄金城667733学报（医学版）等期刊编委。担任教育部科技奖励、国家自然科学基金优青、面上及青年基金项目等评审专家。获得中国发明专利20件，美国专利3件；主编教材\专著2部。指导学生获得“互联网+”大学生创新创业大赛省赛金奖、全国总决赛银奖，全国基础医学大赛金奖等。研究成果获教育部二等奖、中国辐射防护学会二等奖、中国核能行业协会二等奖、四川省教学成果一等奖等奖励。

主编《放射生物学实验教程》和《肿瘤放射生物学实验教程》

讲授课程：《药理学》、《法医病理学》、《生命的坚韧》等

教学获奖：四川省教学成果一等奖、新黄金城667733教学成果特等奖

已发表的学术论文：

1.Liu P, Yu D, Sheng W, Geng F, Zhang J*, Zhang S*. PPARα activation by fenofibrate ameliorates radiation‐induced skin injury. J Eur Acad Dermatol Venereol. 2022;36(3):e207-e210.

2. Geng F, Chen J, Tang S, Azzam EI, Zhang J*, Zhang S*. Additional Evidence for Commonalities between COVID-19 and Radiation Injury: Novel Insight into COVID-19 Candidate Drugs. Radiat Res. 2022;198(3):306-317.

3. Yu D*, Zhang S, Mo W, Jiang Z, Wang M, An L, Wang Y, Liu Y, Jiang S, Wu A, Cao J, Zhang S*. Transplantation of the Stromal Vascular Fraction (SVF) Mitigates Severe Radiation-Induced Skin Injury. Radiat Res. 2021;196(3):250-260.

4. Qiu Y, Gao Y, Yu D, Zhong L, Cai W, Ji J, Geng F, Tang G, Zhang H, Cao J, Zhang J*, Zhang S*. Genome-wide analysis reveals zinc transporter ZIP9 regulated by DNA methylation promotes radiation-induced skin fibrosis via the TGF-β signaling pathway. J Invest Dermatol. 2020;140:94-102.

5. Xiao Y, Mo W, Jia H, Yu D, Qiu Y, Jiao Y, Zhu W, Koide H, Cao J*, Zhang S*. Ionizing radiation induces cutaneous lipid remolding and skin adipocytes confer protection against radiation-induced skin injury. J Dermatol Sci. 2020;97(2):152-160.

6. Cao J, Zhu W, Yu D, Pan L, Zhong L, Xiao Y, Gao Y, Jiao Y, Zhang Q, Ji J, Yang H, Zhang S*, Cao J*. The Involvement of SDF-1α/CXCR4 Axis in Radiation-Induced Acute Injury and Fibrosis of Skin. Radiat Res. 2019;192(4):410-421.

7.Gu C, Luo J, Lu X, Tang Y, Ma Y, Yun Y, Cao J, Cao J, Huang Z, Zhou X*, Zhang S*. REV7 confers radioresistance of esophagus squamous cell carcinoma by recruiting PRDX2.Cancer Sci. 2019;110(3):962-972.

8.Xue J, Zhu W, Song J, Jiao Y, Luo J, Yu C, Zhou J, Wu J, Chen M, Ding WQ, Cao J*, Zhang S*. Activation of PPARα by clofibrate sensitizes pancreatic cancer cells to radiation through the Wnt/β-catenin pathway. Oncogene. 2018;37(7):953-962.

9. Xue J, Yu C, Sheng W, Zhu W, Luo J, Zhang Q, Yang H, Cao H, Wang W, Zhou J, Wu J, Cao P, Chen M, Ding WQ, Cao J*, Zhang S*. The Nrf2/GCH1/BH4 axis ameliorates radiation-induced skin injury by modulating the ROS cascade. J Invest Dermatol. 2017;137(10):2059–2068.

10. Nie J, Zhang J, Wang L, Lu L, Yuan Q, An F, Zhang S*, Jiao Y*. Adipocytes promote cholangiocarcinoma metastasis through fatty acid binding protein 4. J Exp Clin Cancer Res. 2017;36(1):183.

11. Wang W, Luo J, Sheng W, Xue J, Li M, Ji J, Liu P, Zhang X, Cao J, Zhang S*. Proteomic profiling of radiation-induced skin fibrosis in rats: targeting the ubiquitin-proteasome system. Int J Radiat Oncol*Biol*Phys.2016;95(2):751-60.

12. Tang Y, Cui Y, Li Z, Jiao Z, Zhang Y, He Y, Cheng G, Zhou Q, Wang W, Zhou X, Luo J*, Zhang S*. Radiation-induced miR-208a increases the proliferation and radioresistance by targeting p21 in human lung cancer cells. J Exp Clin Cancer Res. 2016;35(1):7.

13.Zhang S, Xue J, Zheng J, Wang S, Zhou J, Jiao Y, Geng Y, Wu J, Hannafon BN, Ding WQ*. The superoxide dismutase 1 (SOD1) 3'UTR maintains High expression of the SOD1 gene in cancer cells: The involvement of the RNA binding protein AUF1. Free Radic Biol Med.2015,85:33-44.

14.Zhang S*, Wang W, Gu Q, Xue J, Cao H, Tang Y, Xu X, Cao J*, Zhou J, Wu J, Ding WQ. Protein and miRNA profiling of radiation-induced skin injury in rats: the protective role of peroxiredoxin-6 (PRDX-6) against ionizing radiation. Free Radical Biol & Med. 2014;69:96-107.

15.Zhang S, Chen H, Zhao S, Cao J, Tong J, Lu J, Wu W, Shen H, Wei Q, Lu D*. REV3L 3’UTR 460 T>C polymorphism in microRNA target sites contributes to lung cancer susceptibility. Oncogene.2013:10;32(2):242-50.

国家卫生健康委员核技术医学转化重点实验室首席科学家。